San Francisco is a major economic, political, and cultural hub for Northern California, located in the Bay Area. San Jose is known as a global hub for the high tech industry of Silicon Valley, for hosting the annual conferences, such as Facebook F8 and the Apple Worldwide Developers Conference, and as home to organizations like the Silicon Valley Leadership Group, San Jose State University, and the University of Silicon Valley. San Jose is the largest city in Northern California. It is home to important institutions like San Diego State University, UC San Diego, Naval Base San Diego, and the Maritime Museum of San Diego. Known as the 'birthplace of California', San Diego is famous for its historical landmarks, such as Mission San Diego de Alcalá or Balboa Park. It is the hub of the San Diego–Tijuana metropolitan area, the largest transborder agglomeration in the Californias. San Diego is California's second largest city and its southernmost major city. Los Angeles is home to world famous institutions such as UCLA, USC, the Getty Center, and the Oscars, among numerous others.

LA is the largest economic hub on the West Coast and a global center for international trade and finance. Los Angeles is a global city and famed worldwide as home to the Hollywood film industry and for its influence in popular culture. Los Angeles is the largest city in California and one of the largest cities in the Americas. Also, the United States Census Bureau and the California Department of Finance use different methods for estimating population, so state estimates will differ from those given here. Note: The population figures are for the incorporated areas of the listed cities, as opposed to metropolitan areas, urban areas, or counties. state of California ranked by population, based on estimates for July 1, 2021, by the United States Census Bureau. This is a list of the 100 largest cities in the U.S.

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